Adiponectin is a hormone secreted by fat cells. In adults, blood levels of adiponectin are inversely correlated with body fat percentage and are significantly lower in obesity. In other words, the more obese the patient, the lower the adiponectin levels in the blood. Lower levels of adiponectin have been associated with an increased incidence of obesity-linked cardiovascular diseases such as ischemic heart disease and peripheral artery disease. Low levels of adiponectin have been associated with insulin resistance, type II diabetes, glucose metabolism and lipid metabolism. In addition, adiponectin might play a regulatory role in atherogenesis, endothelial function, and vascular remodeling. It is also involved in the inflammatory process, and it is important in the genesis of arteriosclerosis and coronary arteritis. It has been suggested that the level of adiponectin may help to estimate the risk of coronary disease and could influence physiological processes such as angiogenesis. Other studies have shown that adiponectin has a direct effect on cardiac cells and facilitates cardiac remodeling in patients suffering from acute cardiac injury. Weight reduction significantly increases the circulating levels of adiponectin.
Adiponectin testing is performed on a blood sample drawn from a vein in the patient’s arm. Additional tests may include Glucose, Insulin levels, Glucose Tolerance Test, Hemoglobin A1c, C-peptide, Leptin, Lipid profile, Liver profile, and CRP.
Reference ranges and specimen collection vary by test method and the laboratory performing this test. To properly evaluate your test results, consult with the ordering physician or your healthcare provider. If you would like to learn more about testing for adiponectin, click here for further information, or you can research one of the references listed below.
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